Monday, December 13, 2010

Nature vs Nurture re Diabetes & Obesity

Genomics.  Genetics.  A rose is still a rose . . . It turns out that when we speak of genetics, we're talking about one specific gene making a big difference, whether autosomal dominant or recessive in the classic Mendelian manner.  However, with new technology, we are now able to delve into genomics, where multiple genes are involved in disease risk.  This week's issue of NEJM has a nice review of our current state of knowledge regarding how genomics affects our risk for diabetes & obesity.  While new advances might help us individually tailor treatment in the future, we're not there yet, not by a long shot.  So let's not forget the old nature vs nurture debate.  Rather than using this study as an excuse to give up, let's refocus on our ability to control our genomic destiny to a great extent by making positive lifestyle choices.

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