The authors arrived at their conclusions by comparing 23 patients who had suffered mild TBI resulting in symptoms for 2 months after their injury to 18 age-matched healthy control subjects. What's scary, in my opinion, is that conventional imaging using CT or MRI typically shows a normal picture w/o any evidence of anatomic injury. Yet this study shows that physiologically, there is tremendous impact (no pun intended) from even mild TBI.
This builds upon a research letter published earlier this month in JAMA in which the authors noted that soccer players who regularly head the ball but without having sustained a history of a concussion had alteration to their white matter compared to matched swimmers who are at very low risk for repetitive subconcussive head trauma. While I'm not ready to change the rules for playing a global sport, I do believe we need to start paying more attention to what we label as a "mild" concussion.
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