The bisphosphonate class of osteoporosis medications just can't seem to win. They've been hung out to dry as causing osteonecrosis of the jaw and most recently, atypical femur fractures. And as of this week, the Canadians have now linked bisphosphonate use to inflammatory eye disease, eg uveitis & scleritis. A retrospective cohort study of 934,147 persons followed for up to 6 years demonstrated an increase risk of uveitis & scleritis in 10,827 bisphosphonate users compared to 923,320 non-users. Granted, this study does not prove cause & effective but rather only demonstrates an association. By doing so, it offers a basis for a hypothesis for future studies. But while we wait for outcomes of a randomized controlled trial, we better remember to add another check-off box to discuss w/potential users of bisphosphonates.