So let's take a moment to review this study where men average weight 80kg were randomized to receive either 50mg, 125mg, 300mg or 600mg of testosterone enanthate weekly (and at the same time randomized to receive either dutasteride daily or placebo). To understand the implications of these testosterone doses, it helps to recall that testosterone cypionate and enanthate are typically dosed at 1mg/kg/week so that the 3 largest doses were really just that - high! In fact, 50mg/wk of testosterone was able to achieve 519ng/dL in those who received dutasteride vs 385ng/dL who received placebo. Those who received 125mg/wk achieved 895ng/dL & 822ng/dL, respectively, while 300mg/wk lead to 1,760ng/dL & 1,702ng/dL respectively. Finally, 600mg/wk (that's 3cc at 200mg/cc) resulted in 3,898ng/dL & 3,578ng/dL on dutasteride vs placebo. Keep in mind that normal testosterone levels were considered 300-1,200ng/dL by the lab used for before & after measurements such that the 2 largest doses lead to supraphysiologic levels.
Now, don't get me wrong. I'm not suggesting for a minute that we supplement testosterone to supraphysiologic levels. There are too many other issues at play here. We have to monitor for mood change (possible 'roid rage), hair loss, prostate enlargement (not cancer), gynecomastia, (ironic) loss of libido, polycythemia, decrease in HDL, and increase in blood pressure. The latter three combine to increase one's risk of thrombotic events, eg heart attack & stroke. All I'm suggesting is that within the normal range, there is the potential for more muscle mass & strength without the side effects associated with supraphysiologic levels. So make sure you follow your patients closely (or if you're the patient, make sure your doctor knows what s/he is following).