Thursday, November 10, 2011

Fibrates: Clinical Outcomes vs Lipid Lowering Part 2

Earlier this summer, I made a quick note of how physicians have been prescribing more & more fibrates (fibric acids) for lipid lowering even though the ACCORD study published in 2010 demonstrated no benefit from fibrates in preventing heart attacks & strokes in diabetics.  

Well, Dr. Eva H pointed out that the FDA finally stepped in yesterday with a safety announcement updating the product insert labeling and patient Medication Guide with details of the above noted study (not yet completed as of today).

Given that there's no clinical outcome benefit to using this drug in diabetics, the bigger question to be raised is whether there's any benefit for use in the larger population as a whole.  In fact, the FDA is requiring the manufacturer to sponsor a randomized, double-blind, placebo-controlled trial to study whether the use of fibrates can reduce residual risk in those patients who've already achieved the lowest LDL goals.  Stay tuned!

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